S.A. Agarkova, O.V. Filatova, G.I. Kostyuchenko
Aggregative Activity of Platelets in the Blood of Women with Type 2 Diabetes on the Background of Taking Acetylsalicylic Acid
The total of 94 women with Type 2 diabetes (T2D) within the age range of 43–82 was checked as part of the study. The markers of platelets aggregative activity were indicated by the turbidimetric method with the help of the optical aggregometer «Chrono-log, 490» (USA), standard inducers of aggregation (ADP, epinephrine, collagen) being used. The reduction of the induced platelets aggregation level is exhibited depending on the inducers of aggregation (epinephrine — up to 79%, collagen — up to 73%, ADP — up to 56%). The frequency of aspirin resistance on the background of ASA therapy equals to 33–91% depending on the inducer of aggregation (33% while using epinephrine, 84% — collagen, 91% — ADP). The content of glucose, glycosylated hemoglobin, cholesterol and triglycerides in the blood serum of those T2D patients taking acetylsalicylic acid (ASA) and not taking it, is not significantly different in terms of statistics. The level of these markers in the groups of “aspirin resistant” and “aspirin sensitive” patients is not significantly different in terms of statistics as well. Any connection between the aggregative activity of platelets and the markers of carbohydrate and lipid profiles is not noticed. The phenomenon of “aspirin resistance” on the background of T2D is self-sufficient. A very strong, almost functional connection between the aggregative activity of platelets and the levels of glycosylated hemoglobin (r = 0,95; р = 0,05) and cholesterol (r = 0,97; р = 0,03) was disclosed in the subgroup of aspirin resistant patients with the level of glucose in blood serum controlled by metformin, epinephrine being used as the inducer of aggregation.
Key words: acetylsalicylic acid, aspirin resistance, optical aggregometry, Type 2 diabetes
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