Study of blood lipid spectrum biochemical parameters of 1058 unorganized Barnaul residents revealed their high frequency. In 79% of the examined persons expressed deviations from reference lipid spectrum values have been mentioned. The urban unorganized residents revealed a high rate of lipid metabolism disorders; in particular, combined dyslipidemia (DLP) dominated 2b type (atherogenic). Atherogenic dyslipidemia was found in 69,9 ± 2,2% of cases, and in 17,2 ± 1,8% — combined DLP. Reduced level of atherogenic violations antirisk factor — HDL cholesterol — 47,36 ± 1,66% was observed among examined people on the background of atherogenic changes in the form of increasing total cholesterol level (TC), triglycerides and LDL cholesterol. Moderately positive correlation of TC with triglyceride is a prerequisite for the development of combined DLP of the population. High and moderate values of connection indicators of the TC levels with rated parameters of LDL cholesterol (r = 0,94, p < 0,001), IA (r = 0,45, p < 0,001)show the increase of TC in the significant share of people due to the atherogenic fraction.