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Известия
Izvestiya of Altai State
University Journal
 The News of Altai State University

 Архив журнала «Известия АлтГУ», начиная с 2017 г., размещен на новой версии сайта http://izvestiya.asu.ru
 Актуальная информация о журнале размещена на новой версии сайта http://izvestiya.asu.ru

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3-2(79)2013
  BIOLOGICAL SCIENCIES

Yu. V. Korenovsky, S. A. El’chaninova

Effect of Hypoxia on the Expression of Matrix Metalloproteinase-1 in Cell Line HT1080

Effect of hypoxia on the mRNA and protein of matrix metalloproteinase-1 (MMP-1) expression in HT1080 human fibrosarcoma cells has been investigated. Hypoxia caused an increase of mRNA and protein expression of MMP-1. Hyperexpression of superoxide dismutase-2 (SOD-2) increased mRNA and protein of MMP-1 synthesis. Simultaneous overexpression of SOD-2 and catalase suppressed mRNA and protein of MMP-1 synthesis.

DOI 10.14258/izvasu(2013)3.2-04

Key words: hypoxia, cell culture, MMP-1, superoxide dismutase, catalase

Full text at PDF, 299Kb. Language: Russian.

 
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