Some variants of coaxial measuring cells for 50 Ohm line and complex permittivity measurements of liquid and disperse matters in 0.01–16 GHz frequency band has been considered. Numerical modeling using finite difference method in time domain has been carried out. TEM-wave propagation through cells has been analyzed and S-parameters were calculated. Comparative analysis of considered cells has been carried out. Conclusions about its application to complex permittivity measurement in frequency band 0.01–16 GHz has been formulated. Technical features of arbitrary variants have been considered. Experimental results of the voltage standing wave ratio for one of the variants of the proposed designs have been presented. Good agreement between the experimental data and the results of numericalmodeling in a frequency band 0.01–12 GHz is observed. The disagreement between the model and experimental data in the frequency band 12–16 GHz can be explained by the errors in the cell geometry and the finite conductivity of the conductors.