Economic security and social and economic development of the region directly depend on the industrial potential of entities engaged in real sector of economy and their innovative activity. The need of continuous development taking place today combined with growing market volatility, inflation, insufficient information prompt unstable market conditions under which the entities work. In turn, uncertainties subdivided into objective uncertainties (that is, connected with stochastic character of production and external environment) and subjective uncertainties (caused by absence of information on possible changes of production and environmental parameters), may serve the risks-promoting factor. The article considers information risk as one of important components of risks of the balanced social and economic development of the region, in correlation with risks of entities engaged in real sector of economy, increasing entropy of information field in the process of interaction of the factors responsible for economic security.